Key formulation variables in tableting of coated pellets
نویسندگان
چکیده
منابع مشابه
Key Formulation Variables in Tableting of Coated Pellets
Multiple unit controlled release dosage forms offer various advantages over their single unit counterparts. Most of these advantages are associated with the uniform distribution of multiparticulates throughout the gastrointestinal tract. Though coated pellets can be filled into hard gelatin capsules, tablet formulation is the preferred one because of various advantages associated with it. Howev...
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This study was aimed at a biopharmaceutical evaluation of a new oral dosage form of tramadol hydrochloride (TH)--slow release tablets obtained by hot tableting of coated pellets, 100 mg (TP), compared to the conventional slow release tablets, Tramal Retard, 100 mg (TR). Both TP and TR formulations showed a similar release profile of TH (f2 was 71) in in vitro release studies. The in vivo study ...
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Coated multiparticulate systems are increasingly popular on the market. Their manufacture in a fluid bed often requires polymer binders. Polymers have been widely studied as inhibitors of crystallization [1]. Migration of drugs into the coating layer has also been described [2] but the influence of the coating polymers on the crystallization of the drug is yet to be studied in more depth. In ou...
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Objective: The aim of the present study is to formulate and evaluate enteric coated pellets of Rifampicin and Isoniazid with improved Rifampicin stability in invitro conditions. Methodology: Two different capsule formulations of these drugs were prepared. Formulation-I contains immediate release uncoated pellets of Rifampicin and Isoniazid. Formulation-IIcontains immediate release enteric coate...
متن کاملMechanisms controlling drug release from coated pellets.
Since the use of PEG-coated pellets for the first oral sustainedrelease formulation in 1952, coated pellets have been used extensively to control the drug release kinetics. The term “pellet” has been used interchangeably with other terms, such as bead, sphere, granule, and particle. A large number of drug products have been available to patients. Despite extensive use of the coated pellets, the...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2008
ISSN: 0250-474X
DOI: 10.4103/0250-474x.45391